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Article

The Ciliogenic Transcription Factor RFX3 Regulates Early Midline Distribution of Guidepost Neurons Required for Corpus Callosum Development

29 Mar 2012

Abstract excerpt

The corpus callosum (CC) is the major commissure that bridges the cerebral hemispheres. Agenesis of the CC is associated with human ciliopathies, but the origin of this default is unclear. Regulatory Factor X3 (RFX3) is a transcription factor involved in the control of ciliogenesis, and Rfx3-deficient mice show several hallmarks of ciliopathies including left-right asymmetry defects and hydrocephalus. Here we...

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PMID: 22479201
DOI: 10.1371/journal.pgen.1002606

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The Ciliogenic Transcription Factor RFX3 Regulates Early Midline Distribution of Guidepost Neurons Required for Corpus Callosum DevelopmentPMID 22479201Read ↗

The role of primary cilia in corpus callosum formation is mediated by production of the Gli3 repressor.Semantic proximity Read ↗

Gli3 is required in Emx1+ progenitors for the development of the corpus callosum.Semantic proximity Read ↗

Gli3 controls corpus callosum formation by positioning midline guideposts during telencephalic patterning.Semantic proximity Read ↗

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The ciliogenic transcription factor Rfx3 is required for the formation of the thalamocortical tract by regulating the patterning of prethalamus and ventral telencephalon.Semantic proximity Read ↗

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ZFP423 regulates early patterning and multiciliogenesis in the hindbrain choroid plexusSemantic proximity Read ↗

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