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Article

Cilia and Hedgehog responsiveness in the mouse.

Proceedings of the National Academy of Sciences of the United States of America - 9 Aug 2005

Huangfu Danwei, Anderson Kathryn V

Abstract excerpt

The intraflagellar transport (IFT) proteins Ift172/Wimple and Polaris/Ift88 and the anterograde IFT motor kinesin-II are required for the production and maintenance of cilia. These proteins are also required for the activation of targets of the mouse Hedgehog (Hh) pathway by Gli transcription factors. The phenotypes of the IFT mutants, however, are not identical to mutants that lack Smoothened (Smo), an essential...

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Identifiers

PMID: 16061793
DOI: 10.1073/pnas.0505328102
PMCID: PMC1183606

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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