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Article

Conditional ablation of the RFX4 isoform 1 transcription factor: Allele dosage effects on brain phenotype.

PloS one - 1 Jan 2018

Xu Ping, Morrison James P, Foley Julie F, Stumpo Deborah J, Ward Toni, Zeldin Darryl C, Blackshear Perry J

Abstract excerpt

Regulatory factor X4 (RFX4) isoform 1 is a recently discovered isoform of the winged helix transcription factor RFX4, which can bind to X-box consensus sequences that are enriched in the promoters of cilia-related genes. Early insertional mutagenesis studies in mice first identified this isoform, and demonstrated that it was crucial for mouse brain development. RFX4 isoform 1 is the only RFX4 isoform...

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Identifiers

PMID: 29298325
DOI: 10.1371/journal.pone.0190561
PMCID: PMC5752003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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