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Article

The IRS2 Gly1057Asp variant is associated with human longevity.

The journals of gerontology. Series A, Biological sciences and medical sciences - 1 Mar 2010

Barbieri Michelangela, Rizzo Maria Rosaria, Papa Michela, Boccardi Virginia, Esposito Antonietta, White Morris F, Paolisso Giuseppe

Abstract excerpt

BACKGROUND: Reduced insulin and insulin-like growth factor-1 (IGF-1) signaling extends the life span of invertebrate and mammals. Recently, reduced insulin receptor substrate-2 (IRS2) signaling was found associated with increased longevity in mice. The aim of our study was to evaluate whether a common polymorphism (Gly1057Asp) in human IRS2 gene is associated with human longevity. METHODS: Six hundred...

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Source

Identifiers

PMID: 19887537
DOI: 10.1093/gerona/glp154

Genes

IRS2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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