Article
A polymorphic variant of the insulin-like growth factor 1 (IGF-1) receptor correlates with male longevity in the Italian population: a genetic study and evaluation of circulating IGF-1 from the "Treviso Longeva (TRELONG)" study.
BMC geriatrics - 21 May 2009
Albani Diego, Batelli Sara, Polito Letizia, Vittori Angelica, Pesaresi Marzia, Gajo Giovanni Battista, De Angeli Sergio, Zanardo Andrea, Gallucci Maurizio, Forloni Gianluigi
Abstract excerpt
BACKGROUND: An attenuation of the insulin-like growth factor 1 (IGF-1) signaling has been associated with elongation of the lifespan in simple metazoan organisms and in rodents. In humans, IGF-1 level has an age-related modulation with a lower concentration in the elderly, depending on hormonal and genetic factors affecting the IGF-1 receptor gene (IGF-1R). METHODS: In an elderly population from North-eastern...
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