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Article

Metabolic effects of the Gly1057Asp polymorphism in IRS-2 and interactions with obesity.

Diabetes - 1 Jun 2003

Stefan Norbert, Kovacs Peter, Stumvoll Michael, Hanson Robert L, Lehn-Stefan Angela, Permana Paska A, Baier Leslie J, Tataranni P Antonio, Silver Kristi, Bogardus Clifton

Abstract excerpt

Insulin receptor substrate (IRS)-2 plays an important role in insulin signaling and its disruption results in diabetes in mice. In humans, the IRS-2 Gly1057Asp substitution was associated with lower risk of type 2 diabetes in lean individuals, but with a higher risk in obese individuals. To clarify the role of IRS-2 on the development of type 2 diabetes and obesity in Pima Indians, and particularly to investigate...

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Identifiers

PMID: 12765968
DOI: 10.2337/diabetes.52.6.1544

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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