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Article

Human insulin/IGF-1 and familial longevity at middle age

24 Jul 2009

Abstract excerpt

Recently, we have shown that compared to controls, long-lived familial nonagenarians (mean age: 93.4 years) from the Leiden Longevity Study displayed a lower mortality rate, and their middle-aged offspring displayed a lower prevalence of cardio-metabolic diseases, including diabetes mellitus. The evolutionarily conserved insulin/IGF-1 signaling (IIS) pathway has been implicated in longevity in model organisms,...

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PMID: 20157552
DOI: 10.18632/aging.100071

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