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Article

Discovery of functional gene variants associated with human longevity: opportunities and challenges.

The journals of gerontology. Series A, Biological sciences and medical sciences - 1 Apr 2012

Tazearslan Cagdas, Cho Miook, Suh Yousin

Abstract excerpt

Age is a major risk factor for many human diseases. Extremely long-lived individuals, such as centenarians, have managed to ward off age-related diseases and serve as human models to search for the genetic factors that influence longevity. The discovery of evolutionarily conserved pathways with major impact on life span in animal models has provided tantalizing opportunities to test the relevance of these...

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Identifiers

PMID: 22156437
DOI: 10.1093/gerona/glr200
PMCID: PMC3309874

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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