Article
A/ASP/VAL allele combination of IGF1R, IRS2, and UCP2 genes is associated with better metabolic profile, preserved energy expenditure parameters, and low mortality rate in longevity.
Age (Dordrecht, Netherlands) - 1 Feb 2012
Barbieri Michelangela, Boccardi Virginia, Esposito Antonietta, Papa Michela, Vestini Francesco, Rizzo Maria Rosaria, Paolisso Giuseppe
Abstract excerpt
A large array of gene involved in human longevity seems to be in relationship with insulin/IGF1 pathway. However, if such genes interact each other, or with other genes, to reduce the age-related metabolic derangement and determine the long-lived phenotype has been poorly investigated. Thus, we tested the role of interchromosomal interactions among IGF1R, IRS2, and UCP2 genes on the probability to reach extreme...
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