Article
Gene set analysis of GWAS data for human longevity highlights the relevance of the insulin/IGF-1 signaling and telomere maintenance pathways.
Age (Dordrecht, Netherlands) - 1 Feb 2013
Deelen Joris, Uh Hae-Won, Monajemi Ramin, van Heemst Diana, Thijssen Peter E, Böhringer Stefan, van den Akker Erik B, de Craen Anton J M, Rivadeneira Fernando, Uitterlinden André G, Westendorp Rudi G J, Goeman Jelle J, Slagboom P Eline, Houwing-Duistermaat Jeanine J, Beekman Marian
Abstract excerpt
In genome-wide association studies (GWAS) of complex traits, single SNP analysis is still the most applied approach. However, the identified SNPs have small effects and provide limited biological insight. A more appropriate approach to interpret GWAS data of complex traits is to analyze the combined effect of a SNP set grouped per pathway or gene region. We used this approach to study the joint effect on human...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.