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Article

Reduced insulin/IGF-1 signalling and human longevity.

Aging cell - 1 Apr 2005

van Heemst Diana, Beekman Marian, Mooijaart Simon P, Heijmans Bastiaan T, Brandt Bernd W, Zwaan Bas J, Slagboom P Eline, Westendorp Rudi G J

Abstract excerpt

Evidence is accumulating that aging is hormonally regulated by an evolutionarily conserved insulin/IGF-1 signalling (IIS) pathway. Mutations in IIS components affect lifespan in Caenorhabditis elegans, Drosophila melanogaster and mice. Most long-lived IIS mutants also show increased resistance to oxidative stress. In D. melanogaster and mice, the long-lived phenotype of several IIS mutants is restricted to...

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Source

Identifiers

PMID: 15771611
DOI: 10.1111/j.1474-9728.2005.00148.x

Genes

IGF1
IRS1
GHRHR
INS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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