Article
Stage III colorectal cancer: molecular disparity between primary cancers and lymph node metastases.
Annals of surgical oncology - 1 Feb 2010
Messick Craig A, Church James M, Liu Xiuli, Ting Angela H, Kalady Matthew F
Abstract excerpt
BACKGROUND: Colorectal cancers (CRCs) may be classified according to underlying genetic and epigenetic changes including microsatellite instability (MSI) and the CpG island methylator phenotype (CIMP). However the relevance of these molecular characteristics, which are being increasingly used to guide adjuvant therapy, has not been defined for metastatic disease. Since adjunct chemotherapy is designed to prevent...
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