Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

DNA Methylation Profiles of Primary Colorectal Carcinoma and Matched Liver Metastasis

21 Nov 2011

Abstract excerpt

BACKGROUND: The contribution of DNA methylation to the metastatic process in colorectal cancers (CRCs) is unclear. METHODS: We evaluated the methylation status of 13 genes (MINT1, MINT2, MINT31, MLH1, p16, p14, TIMP3, CDH1, CDH13, THBS1, MGMT, HPP1 and ERα) by bisulfite-pyrosequencing in 79 CRCs comprising 36 CRCs without liver metastasis and 43 CRCs with liver metastasis, including 16 paired primary CRCs and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Genomics and Diagnostics
Share to Colorectal Cancer Treatments and Studies
Share to Epigenetics and DNA Methylation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 22132162
DOI: 10.1371/journal.pone.0027889

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

DNA Methylation Profiles of Primary Colorectal Carcinoma and Matched Liver MetastasisPMID 22132162Read ↗

The DNA hypermethylation phenotype of colorectal cancer liver metastases resembles that of the primary colorectal cancers.Semantic proximity Read ↗

Distinct profiles of epigenetic evolution between colorectal cancers with and without metastasis.Semantic proximity Read ↗

DNA methylation predicts recurrence from resected stage III proximal colon cancer.Semantic proximity Read ↗

Differences in genome, transcriptome, miRNAome, and methylome in synchronous and metachronous liver metastasis of colorectal cancerSemantic proximity Read ↗

The transition from primary colorectal cancer to isolated peritoneal malignancy is associated with a hypermutant, hypermethylated stateSemantic proximity Read ↗

Targeted DNA Methylation Analysis by High-Throughput Sequencing in Hepatic Carcinoma Tissue and Adjacent Normal TissuesSemantic proximity Read ↗

Landscape of Genome-Wide DNA Methylation of Colorectal Cancer MetastasisSemantic proximity Read ↗

Stage III colorectal cancer: molecular disparity between primary cancers and lymph node metastases.Semantic proximity Read ↗

Progressive alteration of DNA methylation of Alu, MGMT, MINT2, and TFPI2 genes in colonic mucosa during colorectal cancer developmentSemantic proximity Read ↗

Expression and promoter DNA methylation of MLH1 in colorectal cancer and lung cancerSemantic proximity Read ↗

RAS/BRAF wild-type metastatic high-methylated colorectal cancer has gene expression patterns related to MSI-H and BRAF V600E mutant: a translational research.Semantic proximity Read ↗

DNA methylation profiling reliably distinguishes pulmonary enteric adenocarcinoma from metastatic colorectal cancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.