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Article

Adverse prognostic impact of the CpG island methylator phenotype in metastatic colorectal cancer.

British journal of cancer - 12 Jul 2016

Cha Yongjun, Kim Kyung-Ju, Han Sae-Won, Rhee Ye Young, Bae Jeong Mo, Wen Xianyu, Cho Nam-Yun, Lee Dae-Won, Lee Kyung-Hun, Kim Tae-Yong, Oh Do-Youn, Im Seock-Ah, Bang Yung-Jue, Jeong Seung-Yong, Park Kyu Joo, Kang Gyeong Hoon, Kim Tae-You

Abstract excerpt

BACKGROUND: The association between the CpG island methylator phenotype (CIMP) and clinical outcomes in metastatic colorectal cancer remains unclear. We investigated the prognostic impact of CIMP in patients with metastatic colorectal cancer treated with systemic chemotherapy. METHODS: Eight CIMP-specific promoters (CACNA1G, IGF2, NEUROG1, RUNX3, SOCS1, CDKN2A, CRABP1, and MLH1) were examined. The CIMP status was...

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Source

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Identifiers

PMID: 27310704
DOI: 10.1038/bjc.2016.176
PMCID: PMC4947699

Genes

CRABP1
IGF2
MLH1
NEUROG1
RUNX3
SOCS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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