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Article

Genetic and epigenetic alterations in primary colorectal cancers and related lymph node and liver metastases.

Cancer - 15 Jan 2013

Miranda Elena, Bianchi Paolo, Destro Annarita, Morenghi Emanuela, Malesci Alberto, Santoro Armando, Laghi Luigi, Roncalli Massimo

Abstract excerpt

BACKGROUND: Colorectal cancer (CRC) prognosis and survival are strictly related to the development of distant metastases. New targeted therapies have increased patient survival, but the objective response rate is still very limited, partially because of a traditional focus on designing treatment according to the molecular profile of the primary tumor regardless the diversity between the primary tumor and...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 22786759
DOI: 10.1002/cncr.27722

Genes

KRAS
BRAF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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