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Article

The DNA hypermethylation phenotype of colorectal cancer liver metastases resembles that of the primary colorectal cancers.

BMC cancer - 6 Apr 2020

Orjuela Stephany, Menigatti Mirco, Schraml Peter, Kambakamba Patryk, Robinson Mark D, Marra Giancarlo

Abstract excerpt

BACKGROUND: Identifying molecular differences between primary and metastatic colorectal cancers-now possible with the aid of omics technologies-can improve our understanding of the biological mechanisms of cancer progression and facilitate the discovery of novel treatments for late-stage cancer. We compared the DNA methylomes of primary colorectal cancers (CRCs) and CRC metastases to the liver. Laser...

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Identifiers

PMID: 32252665
DOI: 10.1186/s12885-020-06777-6
PMCID: PMC7137338

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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