Article
Genetic and molecular diversity of colon cancer hepatic metastases.
Surgery - 1 Aug 2009
Messick Craig A, Sanchez Julian, Dejulius Kathryn L, Church James M, Kalady Matthew F
Abstract excerpt
BACKGROUND: Colon cancer arises through distinct molecular pathways resulting in diverse tumor populations demonstrated by differences in microsatellite instability (MSI), CpG island methylator phenotype (CIMP), and mutations in oncogenes KRAS and BRAF. Although these molecular differences are well-described for primary neoplasms, the molecular nature of hepatic metastases is not well-characterized. This study...
Topics
- Adenocarcinoma
- Adult
- Aged
- Colonic Neoplasms
- CpG Islands
- Female
- Genes, ras
- Humans
- Liver Neoplasms
- Male
- Microsatellite Instability
- Middle Aged