Article

Metastasis-associated DNA methylation alterations persist after accounting for immune and stromal cell heterogeneity in primary colorectal tumors

2026-07-14

Abstract excerpt

<title>Abstract</title> <p>Background Metastatic colorectal cancer (CRC) remains a major cause of cancer mortality, yet how epigenetic states within the tumor microenvironment (TME) relate to metastatic progression has not been fully characterized. Although aberrant DNA methylation has been implicated in cancer progression, many studies do not account for immune and stromal cell composition, which can confound b...

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Literature Corpus work: f51fb60f-c87b-5d12-9314-4c63098fbb27
DOI: 10.21203/rs.3.rs-9657747/v1

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