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Molecular differences between lymph nodes and distant metastases compared with primaries in colorectal cancer patients

27 Oct 2021

Abstract excerpt

Lymph nodes (LNs) and distant metastases can arise from independent subclones of the primary tumor. Herein, we characterized the molecular landscape and the differences between LNs, distant metastases and primary colorectal cancers (CRCs). Samples were analyzed using next generation sequencing (NGS, MiSeq on 47 genes, NextSeq on 592 genes) and immunohistochemistry. Tumor mutational burden (TMB) was calculated...

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PMID: 34707195
DOI: 10.1038/s41698-021-00230-y

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