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Article

Distinct profiles of epigenetic evolution between colorectal cancers with and without metastasis.

The American journal of pathology - 1 Apr 2011

Ju Hai-Xing, An Byonggu, Okamoto Yasuyuki, Shinjo Keiko, Kanemitsu Yukihide, Komori Koji, Hirai Takashi, Shimizu Yasuhiro, Sano Tsuyoshi, Sawaki Akira, Tajika Masahiro, Yamao Kenji, Fujii Makiko, Murakami Hideki, Osada Hirotaka, Ito Hidemi, Takeuchi Ichiro, Sekido Yoshitaka, Kondo Yutaka

Abstract excerpt

Liver metastasis is a fatal step in the progression of colorectal cancer (CRC); however, the epigenetic evolution of this process is largely unknown. To decipher the epigenetic alterations during the development of liver metastasis, the DNA methylation status of 12 genes, including 5 classical CpG island methylator phenotype (CIMP) markers, was analyzed in 62 liver metastases and in 78 primary CRCs (53 stage...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Methylation

Share to Epigenesis, Genetic

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Share to Gene Expression Regulation, Neoplastic

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Source

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Identifiers

PMID: 21406167
DOI: 10.1016/j.ajpath.2010.12.045
PMCID: PMC3078452

Genes

MGMT
TIMP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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