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Article

The role of autophosphorylation in modulation of erbB-2 transforming function.

The New biologist - 1 Feb 1990

Segatto O, Lonardo F, Pierce J H, Bottaro D P, Di Fiore P P

Abstract excerpt

The product of the erbB-2 gene is a 185-kD receptor-like glycoprotein. erbB-2 gp185 displays constitutive tyrosine kinase activity and transforms NIH 3T3 cells when expressed 100-fold over the normal levels. We have analyzed the role of tyrosine kinase function and of receptor autophosphorylation in the regulation of erbB-2 biological activity. Abolition of erbB-2 gp185 tyrosine kinase function resulted in...

Topics

Animals
Base Sequence
Binding Sites
Cell Line
DNA
Molecular Sequence Data
Mutation
Phosphorylation
Protein-Tyrosine Kinases
Proto-Oncogene Proteins
Receptor, ErbB-2
Transformation, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Tyrosine

Source

Identifiers

PMID: 1982072

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1982072-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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