Autophosphorylation modulates the kinase activity and oncogenic potential of the Met receptor tyrosine kinase.

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Article

Autophosphorylation modulates the kinase activity and oncogenic potential of the Met receptor tyrosine kinase.

Oncogene - 1 Jul 1994

Rodrigues G A, Park M

Abstract excerpt

The met oncogene is activated by a genomic rearrangement that generates a hybrid protein containing tpr sequences at its amino terminus fused directly to the met (hepatocyte growth factor/scatter factor) receptor tyrosine kinase domain. The resultant p65Tpr-Met hybrid protein possesses tyrosine k...

Topics

3T3 Cells
Amino Acid Sequence
Animals
Base Sequence
Cell Line
Cell Transformation, Neoplastic
DNA Primers
Gene Expression Regulation
Hepatocyte Growth Factor
Mice
Molecular Sequence Data
Mutation
Phosphorylation
Proto-Oncogene Proteins
Proto-Oncogene Proteins c-met
Rats
Rats, Inbred F344
Receptor Protein-Tyrosine Kinases

Source

Open in PubMed

Identifiers

PMID: 8208547

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8208547-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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