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Article

Autophosphorylation modulates the kinase activity and oncogenic potential of the Met receptor tyrosine kinase.

Oncogene - 1 Jul 1994

Rodrigues G A, Park M

Abstract excerpt

The met oncogene is activated by a genomic rearrangement that generates a hybrid protein containing tpr sequences at its amino terminus fused directly to the met (hepatocyte growth factor/scatter factor) receptor tyrosine kinase domain. The resultant p65Tpr-Met hybrid protein possesses tyrosine kinase activity and is constitutively phosphorylated on tyrosine in vivo. A substitution of the conserved lysine in the...

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PMID: 8208547

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Autophosphorylation modulates the kinase activity and oncogenic potential of the Met receptor tyrosine kinase.PMID 8208547Read ↗

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Activating mutations for the Met tyrosine kinase receptor in human cancerSemantic proximity Read ↗

Enhanced expression and phosphorylation of the MET oncoprotein by glioma‐specific PTPRZ1–MET fusionsSemantic proximity Read ↗

Two mutations affecting conserved residues in the Met receptor operate via different mechanisms.Semantic proximity Read ↗

Regulation of the wild-type and Y1235D mutant Met kinase activation.Semantic proximity Read ↗

The multisubstrate docking site of the MET receptor is dispensable for MET-mediated RAS signaling and cell scattering.Semantic proximity Read ↗

erbB-2 autophosphorylation is required for mitogenic action and high-affinity substrate coupling.Semantic proximity Read ↗

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