Increased oncogenic potential of ErbB is associated with the loss of a COOH-terminal domain serine phosphorylation site.

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Article

Increased oncogenic potential of ErbB is associated with the loss of a COOH-terminal domain serine phosphorylation site.

The Journal of biological chemistry - 25 Apr 1992

Theroux S J, Taglienti-Sian C, Nair N, Countaway J L, Robinson H L, Davis R J

Abstract excerpt

The erbB oncogene encodes an altered form of the epidermal growth factor (EGF) receptor that lacks the extracellular ligand binding domain. This oncogene is exclusively leukemogenic. However, an increase in oncogenic potential and a broadening of the tissue specificity of tumor formation occurs after retroviral transduction of erbB. The increased oncogenic potential correlates with structural alterations within...

Topics

3T3 Cells
Alanine
Animals
Cell Transformation, Neoplastic
Chick Embryo
Glutamates
Glutamic Acid
Kinetics
Mice
Mutation
Oncogenes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phosphorylation

Plasmids

Protein-Tyrosine Kinases

Proto-Oncogene Proteins

Receptor, ErbB-2

Serine

Source

Open in PubMed

Identifiers

PMID: 1349014

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1349014-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Increased oncogenic potential of ErbB is associated with the loss of a COOH-terminal domain serine phosphorylation site.PMID 1349014Read ↗

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