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Article

Increased oncogenic potential of ErbB is associated with the loss of a COOH-terminal domain serine phosphorylation site.

The Journal of biological chemistry - 25 Apr 1992

Theroux S J, Taglienti-Sian C, Nair N, Countaway J L, Robinson H L, Davis R J

Abstract excerpt

The erbB oncogene encodes an altered form of the epidermal growth factor (EGF) receptor that lacks the extracellular ligand binding domain. This oncogene is exclusively leukemogenic. However, an increase in oncogenic potential and a broadening of the tissue specificity of tumor formation occurs after retroviral transduction of erbB. The increased oncogenic potential correlates with structural alterations within...

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Source

Identifiers

PMID: 1349014

Genes

EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Increased oncogenic potential of ErbB is associated with the loss of a COOH-terminal domain serine phosphorylation site.PMID 1349014Read ↗

Mutational activation of ErbB2 reveals a new protein kinase autoinhibition mechanism.Semantic proximity Read ↗

Functional analysis of receptor tyrosine kinase mutations in lung cancer identifies oncogenic extracellular domain mutations of ERBB2.Semantic proximity Read ↗

A constitutively active ERBB4/HER4 allele with enhanced transcriptional coactivation and cell-killing activities.Semantic proximity Read ↗

Ligand-independent oncogenic transformation by the EGF receptor requires kinase domain catalytic activity.Semantic proximity Read ↗

Activating ERBB4 mutations in non-small cell lung cancer.Semantic proximity Read ↗

Molecular modeling of ErbB4/HER4 kinase in the context of the HER4 signaling network helps rationalize the effects of clinically identified HER4 somatic mutations on the cell phenotype.Semantic proximity Read ↗

Mutational activation of ErbB family receptor tyrosine kinases: insights into mechanisms of signal transduction and tumorigenesis.Semantic proximity Read ↗

Ligand-independent oncogenic signaling by the epidermal growth factor receptor: v-ErbB as a paradigm.Semantic proximity Read ↗

Somatic mutations of ErbB4: selective loss-of-function phenotype affecting signal transduction pathways in cancer.Semantic proximity Read ↗

Tissue-specific transformation by oncogenic mutants of epidermal growth factor receptor.Semantic proximity Read ↗

Mutations in the polybasic juxtamembrane sequence of both plasma membrane- and endoplasmic reticulum-localized epidermal growth factor receptors confer ligand-independent cell transformation.Semantic proximity Read ↗

Identification of a region within the ErbB2/HER2 intracellular domain that is necessary for ligand-independent association.Semantic proximity Read ↗

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