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Article

erbB-2 Overexpression in Human Mammary Epithelial Cells Confers Growth Factor Independence*

1 Aug 1999

Abstract excerpt

Previously, we demonstrated that human breast cancer cells with progressively elevated levels of constitutively tyrosine phosphorylated erbB-2 are independent of growth factors required by normal human mammary epithelial (HME) cells for proliferation in serum-free medium. To determine whether erbB-2 overexpression alone is sufficient to confer the growth factor-independence phenotype in HME cells, the...

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PMID: 10433219
DOI: 10.1210/endo.140.8.6939

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Related research

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Research trail→

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erbB-2 Overexpression in Human Mammary Epithelial Cells Confers Growth Factor Independence*PMID 10433219Read ↗

New model of ErbB-2 over-expression in human mammary luminal epithelial cellsSemantic proximity Read ↗

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ERBB-2 overexpression confers PI 3' kinase-dependent invasion capacity on human mammary epithelial cells.Semantic proximity Read ↗

The ErbB-2/HER2 oncoprotein of human carcinomas may function solely as a shared coreceptor for multiple stroma-derived growth factorsSemantic proximity Read ↗

Elevated expression of activated forms of Neu/ErbB-2 and ErbB-3 are involved in the induction of mammary tumors in transgenic mice: implications for human breast cancer.Semantic proximity Read ↗

A functional screen for genes inducing epidermal growth factor autonomy of human mammary epithelial cells confirms the role of amphiregulin.Semantic proximity Read ↗

Effects of ErbB-2 overexpression on mitogenic signalling and cell cycle progression in human breast luminal epithelial cellsSemantic proximity Read ↗

Protection against mammary tumor growth by vaccination with full-length, modified humanErbB-2 DNASemantic proximity Read ↗

Dominant negative knockout of p53 abolishes ErbB2-dependent apoptosis and permits growth acceleration in human breast cancer cells.Semantic proximity Read ↗

Expression of the p185 encoded by her2 oncogene in normal and transformed human tissuesSemantic proximity Read ↗

C-Src activation by ErbB2 leads to attachment-independent growth of human breast epithelial cells.Semantic proximity Read ↗

Role of steroid hormone and growth factor receptors and proto-oncogenes in the behavior of human mammary epithelial cancer cells in vitro.Semantic proximity Read ↗

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