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Article

Epidermal growth factor receptor juxtamembrane region regulates allosteric tyrosine kinase activation.

Proceedings of the National Academy of Sciences of the United States of America - 4 Dec 2007

Thiel Kristina W, Carpenter Graham

Abstract excerpt

Structural studies of the extracellular and tyrosine kinase domains of the epidermal growth factor receptor (ErbB-1) provide considerable insight into facets of the receptor activation mechanism, but the contributions of other regions of ErbB-1 have not been ascertained. This study demonstrates that the intracellular juxtamembrane (JM) region plays a vital role in the kinase activation mechanism. In the...

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Identifiers

PMID: 18042729
DOI: 10.1073/pnas.0703854104
PMCID: PMC2148274

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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