Article
Agonistic antibodies stimulate the kinase encoded by the neu protooncogene in living cells but the oncogenic mutant is constitutively active.
Proceedings of the National Academy of Sciences of the United States of America - 1 Apr 1990
Yarden Y
Abstract excerpt
The neu protooncogene (also called c-erbB2 and HER-2) undergoes oncogenic activation through a single mutation. The product of the protooncogene, p185neu, probably functions as a receptor for a peptide growth factor. To circumvent the absence of a well-characterized ligand, I generated ligand-mimicking monoclonal antibodies directed to the presumed receptor. These antibodies stimulated tyrosine phosphorylation of...
Topics
- Animals
- Antibodies, Monoclonal
- Antigen-Antibody Complex
- Cell Line
- Cell Transformation, Neoplastic
- Enzyme Activation
- Immunoglobulin Fab Fragments
- Kinetics
- Mice
- Mice, Inbred Strains