Article
The epidermal growth factor receptor and the product of the neu protooncogene are members of a receptor tyrosine phosphorylation cascade.
Proceedings of the National Academy of Sciences of the United States of America - 1 Aug 1990
Connelly P A, Stern D F
Abstract excerpt
The protein product of the neu protooncogene, p185, is a tyrosine kinase with a high degree of sequence homology to the epidermal growth factor (EGF) receptor. Although p185 does not bind EGF, EGF stimulates tyrosine phosphorylation of p185. To determine the mechanism of this interaction we have used a vaccinia virus/bacteriophage T7-based transient gene expression system to induce production of normal and...
Topics
- Animals
- Antibodies, Monoclonal
- Cell Line
- ErbB Receptors
- HeLa Cells
- Humans
- Mice
- Mutation
- Phosphorylation
- Plasmids
- Protein-Tyrosine Kinases