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Article

Mutational activation of ErbB2 reveals a new protein kinase autoinhibition mechanism.

The Journal of biological chemistry - 18 Jan 2008

Fan Ying-Xin, Wong Lily, Ding Jinhui, Spiridonov Nikolay A, Johnson Richard C, Johnson Gibbes R

Abstract excerpt

Autoinhibition plays a key role in the control of protein kinase activity. ErbB2 is a unique receptor-tyrosine kinase that does not bind ligand but possesses an extracellular domain poised to engage other ErbBs. Little is known about the molecular mechanism for ErbB2 catalytic regulation. Here we show that ErbB2 kinase is strongly autoinhibited, and a loop connecting the alphaC helix and beta4 sheet within the...

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Identifiers

PMID: 18039657
DOI: 10.1074/jbc.M708116200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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