Article
NIH/3T3 cells transformed with the activated erbB-2 oncogene can be phenotypically reverted by a kinase deficient, dominant negative erbB-2 variant.
Molecular and cellular endocrinology - 1 Oct 1994
Messerle K, Schlegel J, Hynes N E, Groner B
Abstract excerpt
A single missense mutation in the human erbB-2 proto-oncogene (HER2N) efficiently transforms cultured NIH/3T3 fibroblasts. The transforming allele (HER2VE) contains a glutamic acid residue at position 659, instead of a valine, in the transmembrane region of the growth factor receptor. Receptor ac...
Topics
- 3T3 Cells
- Animals
- Base Sequence
- Cell Division
- Cell Transformation, Neoplastic
- Gene Deletion
- Humans
- Mice
- Molecular Sequence Data
- Mutation
- Phenotype
- Phosphorylation
- Protein-Tyrosine Kinases
- Proto-Oncogene Mas
- Proto-Oncogenes
- Receptor, ErbB-2
- Structure-Activity Relationship