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Article

Role of the Rad52 amino-terminal DNA binding activity in DNA strand capture in homologous recombination.

The Journal of biological chemistry - 27 Nov 2009

Shi Idina, Hallwyl Swee C L, Seong Changhyun, Mortensen Uffe, Rothstein Rodney, Sung Patrick

Abstract excerpt

Saccharomyces cerevisiae Rad52 protein promotes homologous recombination by nucleating the Rad51 recombinase onto replication protein A-coated single-stranded DNA strands and also by directly annealing such strands. We show that the purified rad52-R70A mutant protein, with a compromised amino-terminal DNA binding domain, is capable of Rad51 delivery to DNA but is deficient in DNA annealing. Results from chromatin...

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Share to Chromatin Immunoprecipitation
Share to DNA Breaks, Double-Stranded

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Repair

Share to DNA, Single-Stranded

Share to Electrophoresis, Polyacrylamide Gel

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Share to Rad52 DNA Repair and Recombination Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 19812039
DOI: 10.1074/jbc.M109.057752
PMCID: PMC2785170

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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