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Article

Interaction of yeast Rad51 and Rad52 relieves Rad52-mediated inhibition of de novo telomere addition.

PLoS genetics - 1 Feb 2020

Epum Esther A, Mohan Michael J, Ruppe Nicholas P, Friedman Katherine L

Abstract excerpt

DNA double-strand breaks (DSBs) are toxic forms of DNA damage that must be repaired to maintain genome integrity. Telomerase can act upon a DSB to create a de novo telomere, a process that interferes with normal repair and creates terminal deletions. We previously identified sequences in Saccharomyces cerevisiae (SiRTAs; Sites of Repair-associated Telomere Addition) that undergo unusually high frequencies of de...

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Identifiers

PMID: 32012161
DOI: 10.1371/journal.pgen.1008608
PMCID: PMC7018233

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