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The Carboxyl Terminus of Brca2 Links the Disassembly of Rad51 Complexes to Mitotic Entry

19 Jun 2009

Abstract excerpt

BACKGROUND: The Rad51 recombinase assembles on DNA to execute homologous DNA recombination (HR). This process is essential to repair replication-associated genomic lesions before cells enter mitosis, but how it is started and stopped during the cell cycle remains poorly understood. Rad51 assembly is regulated by the breast cancer suppressor Brca2, via its evolutionarily conserved BRC repeats, and a distinct...

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PMID: 19540122
DOI: 10.1016/j.cub.2009.05.057

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The Carboxyl Terminus of Brca2 Links the Disassembly of Rad51 Complexes to Mitotic EntryPMID 19540122Read ↗

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