Article
The interaction between TPH2 promoter haplotypes and clinical-demographic risk factors in suicide victims with major psychoses.
Genes, brain, and behavior - 1 Feb 2006
De Luca V, Hlousek D, Likhodi O, Van Tol H H M, Kennedy J L, Wong A H C
Abstract excerpt
Tryptophan hydroxylase isoform 2 (TPH2) is a rate-limiting enzyme in the biosynthesis of serotonin (5-HT) and is predominantly localized in the brain. Previous studies have suggested that there is an association between serotonergic dysfunction in the brain and suicidality. This study was designed to examine whether the -473T > A and -8396G > C polymorphisms of the TPH2 gene may be associated with completed...
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