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Article

SNP- and haplotype analysis of the tryptophan hydroxylase 2 gene in alcohol-dependent patients and alcohol-related suicide.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Aug 2007

Zill Peter, Preuss Ulrich W, Koller Gabrielle, Bondy Brigitta, Soyka Michael

Abstract excerpt

Several lines of evidence indicate that disturbances of the central serotonergic system are involved in the pathophysiology of alcohol dependence and suicidal behavior. Recent studies have indicated that a newly identified second isoform of the tryptophan hydroxylase gene (TPH2) is preferentially involved in the rate limiting synthesis of neuronal serotonin. Genetic variations in the TPH2 gene have been...

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Source

Identifiers

PMID: 17251907
DOI: 10.1038/sj.npp.1301318

Genes

TPH2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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SNP- and haplotype analysis of the tryptophan hydroxylase 2 gene in alcohol-dependent patients and alcohol-related suicide.PMID 17251907Read ↗

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SNP and haplotype analysis of a novel tryptophan hydroxylase isoform (TPH2) gene provide evidence for association with major depression.Semantic proximity Read ↗

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Nested association between genetic variation in tryptophan hydroxylase II, bipolar affective disorder, and suicide attempts.Semantic proximity Read ↗

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