No association between a TPH2 promoter polymorphism and mood disorders or monoamine turnover.

doi:10.1016/j.jad.2007.05.031

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

No association between a TPH2 promoter polymorphism and mood disorders or monoamine turnover.

Journal of affective disorders - 1 Feb 2008

Mann J John, Currier Dianne, Murphy Lauren, Huang Yung-yu, Galfalvy Hanga, Brent David, Greenhill Laurence, Oquendo Maria

Abstract excerpt

BACKGROUND: Tryptophan hydroxylase (TPH) is the rate-limiting enzyme in serotonin synthesis. TPH2 is a recently discovered isoform that is expressed predominantly in serotonin neurons. Associations are reported of TPH2 polymorphisms with MDD, bipolar disorder and suicidal behavior. This study examines a single nucleotide polymorphism in the putative promoter region of the TPH2 gene. METHODS: One hundred nine...

Topics

Adult
Bipolar Disorder
Child
Child Abuse
Depressive Disorder, Major
Female
Genotype
Homovanillic Acid
Humans
Hydroxyindoleacetic Acid
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Methoxyhydroxyphenylglycol

Middle Aged

Personality Inventory

Polymorphism, Single Nucleotide

Promoter Regions, Genetic

Suicide, Attempted

Tryptophan Hydroxylase

Source

Open in PubMed Open full text

Identifiers

PMID: 17604842
DOI: 10.1016/j.jad.2007.05.031
PMCID: PMC2756663

Genes

TPH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

No association between a TPH2 promoter polymorphism and mood disorders or monoamine turnover.PMID 17604842Read ↗

TPH2 polymorphisms across the spectrum of psychiatric morbidity: A systematic review and meta-analysis.Semantic proximity Read ↗

Increased risk of suicide attempt in mood disorders and TPH1 genotype.Semantic proximity Read ↗

Association of polymorphisms of the tryptophan hydroxylase 2 gene with risk for bipolar disorder or suicidal behavior.Semantic proximity Read ↗

The interaction between TPH2 promoter haplotypes and clinical-demographic risk factors in suicide victims with major psychoses.Semantic proximity Read ↗

The tryptophan hydroxylase (TPH) 2 gene unlike TPH-1 exhibits no association with stress-induced depression.Semantic proximity Read ↗

TPH2 gene polymorphisms and major depression--a meta-analysis.Semantic proximity Read ↗

Nested association between genetic variation in tryptophan hydroxylase II, bipolar affective disorder, and suicide attempts.Semantic proximity Read ↗

Association between the tryptophan hydroxylase gene and manic-depressive illness.Semantic proximity Read ↗

Tryptophan hydroxylase gene polymorphism (A218C) and suicidal behaviors.Semantic proximity Read ↗

Genetic architecture of the human tryptophan hydroxylase 2 Gene: existence of neural isoforms and relevance for major depression.Semantic proximity Read ↗

Association between single nucleotide polymorphisms of TPH1 and TPH2 genes, and depressive disorders.Semantic proximity Read ↗

Genetics of the serotonergic system in suicidal behavior.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.