Preferential loss of maternal alleles in sporadic Wilms' tumour.

Article

Preferential loss of maternal alleles in sporadic Wilms' tumour.

Oncogene - 1 Nov 1990

Pal N, Wadey R B, Buckle B, Yeomans E, Pritchard J, Cowell J K

Abstract excerpt

Loss of heterozygosity at loci on the short arm of chromosome 11 has been reported in 31% (11/38) of Wilms' tumours in our series. Lymphoblastoid cell lines were prepared from the parents of 10/11 of the patients showing allele loss in their tumours. In 9 of the cases, where the parental origin o...

Topics

Alleles
Chromosomes, Human, Pair 11
DNA Probes
DNA, Neoplasm
Female
Heterozygote
Humans
Kidney Neoplasms
Male
Nucleic Acid Hybridization
Parents
Polymorphism, Restriction Fragment Length
Wilms Tumor

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