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Article

Genetic mosaicism in normal tissues of Wilms' tumour patients.

Nature genetics - 1 Feb 1993

Chao L Y, Huff V, Tomlinson G, Riccardi V M, Strong L C, Saunders G F

Abstract excerpt

We describe the partial loss of heterozygosity (LOH) at chromosome 11p loci in normal tissues (normal kidney and/or blood) from four of 67 Wilms' tumour patients. Autologous tumour DNA showed complete loss of the same, maternally derived, alleles. These observations indicate that the normal tissues were mosaic for cells heterozygous and homozygous for 11p markers and that tumours subsequently developed from the...

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Identifiers

PMID: 8388768
DOI: 10.1038/ng0293-127

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Genetic mosaicism in normal tissues of Wilms' tumour patients.PMID 8388768Read ↗

Loss of heterozygosity in Wilms' tumour involves two distinct regions of chromosome 11.Semantic proximity Read ↗

Loss of heterozygosity in Wilms' tumors, studied for six putative tumor suppressor regions, is limited to chromosome 11.Semantic proximity Read ↗

Loss of alleles at loci on human chromosome 11 during genesis of Wilms' tumour.Semantic proximity Read ↗

Allelotyping in Wilms tumors identifies a putative third tumor suppressor gene on chromosome 11.Semantic proximity Read ↗

Loss of heterozygosity at 7p in Wilms' tumour development.Semantic proximity Read ↗

Loss of heterozygosity in three embryonal tumours suggests a common pathogenetic mechanism.Semantic proximity Read ↗

Allelic loss on chromosome 11p is a less frequent event in bilateral than in unilateral Wilms' tumours.Semantic proximity Read ↗

Frequent loss of heterozygosity at 11p loci in testicular cancer.Semantic proximity Read ↗

Somatic deletion and duplication of genes on chromosome 11 in Wilms' tumours.Semantic proximity Read ↗

Genome-wide loss of maternal alleles in a nephrogenic rest and Wilms' tumour from a BWS patient.Semantic proximity Read ↗

Preferential loss of maternal alleles in sporadic Wilms' tumour.Semantic proximity Read ↗

Identical genetic changes in different histologic components of Wilms' tumors.Semantic proximity Read ↗

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