Genetic mosaicism in normal tissues of Wilms' tumour patients.

doi:10.1038/ng0293-127

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Article

Genetic mosaicism in normal tissues of Wilms' tumour patients.

Nature genetics - 1 Feb 1993

Chao L Y, Huff V, Tomlinson G, Riccardi V M, Strong L C, Saunders G F

Abstract excerpt

We describe the partial loss of heterozygosity (LOH) at chromosome 11p loci in normal tissues (normal kidney and/or blood) from four of 67 Wilms' tumour patients. Autologous tumour DNA showed complete loss of the same, maternally derived, alleles. These observations indicate that the normal tissu...

Topics

Alleles
Child
Child, Preschool
Chromosomes, Human, Pair 11
DNA, Neoplasm
Female
Genes, Wilms Tumor
Genetic Markers
Heterozygote
Homozygote
Humans
Infant
Kidney Neoplasms
Male
Mosaicism
Wilms Tumor

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