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Article

Occasional loss of constitutive heterozygosity at 11p15.5 and imprinting relaxation of the IGFII maternal allele in hepatoblastoma.

Journal of cancer research and clinical oncology - 1 Jan 1994

Montagna M, Menin C, Chieco-Bianchi L, D'Andrea E

Abstract excerpt

The 11p15.5 chromosomal region contains one or more loci involved in congenital developmental abnormalities and in the genesis of embryonal tumors, such as Wilms' tumor, embryonal rhabdomyosarcoma, and hepatoblastoma. In these tumors, a loss of constitutive heterozygosity, selectively involving a specific parental allele, suggests both the presence of onco-suppressor genes and a phenomenon of genomic imprinting....

Topics

Alleles
Child
Child, Preschool
Chromosome Deletion
Chromosomes, Human, Pair 11
Female
Genes, Tumor Suppressor
Genomic Imprinting
Hepatoblastoma
Humans
Infant

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Insulin-Like Growth Factor II

Liver Neoplasms

Male

Source

Identifiers

PMID: 7798299
DOI: 10.1007/BF01194272

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7798299-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Occasional loss of constitutive heterozygosity at 11p15.5 and imprinting relaxation of the IGFII maternal allele in hepatoblastoma.PMID 7798299Read ↗

Relaxation of imprinted genes in human cancer.Semantic proximity Read ↗

Gain of imprinting at chromosome 11p15: A pathogenetic mechanism identified in human hepatocarcinomasSemantic proximity Read ↗

Maintenance of genomic imprinting at the IGF2 locus in hepatoblastoma.Semantic proximity Read ↗

Expression and parental imprinting of the H19 gene in human rhabdomyosarcoma.Semantic proximity Read ↗

Structural and functional abnormalities at 11p15 are associated with the malignant phenotype in sporadic adrenocortical tumors: study on a series of 82 tumors.Semantic proximity Read ↗

Relaxation of insulin-like growth factor II gene imprinting implicated in Wilms' tumour.Semantic proximity Read ↗

Loss of imprinting of IGF2 correlates with hypermethylation of the H19 differentially methylated region in hepatoblastomaSemantic proximity Read ↗

Disruption of imprinted genes at chromosome region 11p15.5 in paediatric rhabdomyosarcoma.Semantic proximity Read ↗

Increased expression of the insulin-like growth factor-II gene in Wilms' tumor is not dependent on loss of genomic imprinting or loss of heterozygosity.Semantic proximity Read ↗

Constitutional UPD for chromosome 11p15 in individuals with isolated hemihyperplasia is associated with high tumor risk and occurs following assisted reproductive technologiesSemantic proximity Read ↗

Mono- and bi-allelic expression of insulin-like growth factor II gene in human muscle tumors.Semantic proximity Read ↗

Relaxation of imprinting of human insulin-like growth factor II gene, IGF2, in sporadic breast carcinomas.Semantic proximity Read ↗

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