Loss of heterozygosity in Wilms' tumour involves two distinct regions of chromosome 11.

Article

Loss of heterozygosity in Wilms' tumour involves two distinct regions of chromosome 11.

Oncogene - 1 Jun 1990

Wadey R B, Pal N, Buckle B, Yeomans E, Pritchard J, Cowell J K

Abstract excerpt

Pairs of tumour and normal DNA samples from 38 Wilms' tumour patients have been investigated for loss of heterozygosity using 12 probes from chromosome 11. Allele loss was detected in only 11 cases (31%). Densitometric analysis showed that allele loss was not due to non-disjunction or hemizygous...

Topics

Alleles
Child
Child, Preschool
Chromosome Mapping
Chromosomes, Human, Pair 11
DNA Probes
DNA, Neoplasm
Heterozygote
Humans
Infant
Infant, Newborn
Kidney Neoplasms
Wilms Tumor

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