Article
Allele loss in Wilms tumors of chromosome arms 11q, 16q, and 22q correlate with clinicopathological parameters.
Genes, chromosomes & cancer - 1 Aug 1998
Klamt B, Schulze M, Thäte C, Mares J, Goetz P, Kodet R, Scheulen W, Weirich A, Graf N, Gessler M
Abstract excerpt
An extended analysis for loss of heterozygosity (LOH) on eight chromosomes was conducted in a series of 82 Wilms tumors. Observed rates of allele loss were: 9.5% (1p), 5% (4q), 6% (6p), 3% (7p), 9.8% (11q), 28% (11p15), 13.4% (16q), 8.8% (18p), and 13.8% (22q). Known regions of frequent allele lo...
Topics
- Alleles
- Antineoplastic Agents
- Chromosomes, Human
- Chromosomes, Human, Pair 11
- Chromosomes, Human, Pair 16
- Chromosomes, Human, Pair 22
- Drug Resistance, Neoplasm
- Humans
- Loss of Heterozygosity
- Wilms Tumor