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Article

Constitutional and somatic deletions of two different regions of maternal chromosome 11 in Wilms tumor.

Genomics - 1 Jul 1990

Jeanpierre C, Antignac C, Beroud C, Lavedan C, Henry I, Saunders G, Williams B, Glaser T, Junien C

Abstract excerpt

Loss of heterozygosity for 11p markers and preferential loss of maternal alleles have been described in Wilms tumor. In this report we describe the molecular characterization of the constitutional and somatic 11p rearrangements in a del(11p13) WAGR patient with Wilms tumor. Both rearrangements led to loss of maternal alleles for two different regions of 11p, namely, 11p13 and 11p14----p15. This result clearly...

Topics

Alleles
Blotting, Southern
Cell Line
Chromosome Aberrations
Chromosome Deletion
Chromosomes, Human, Pair 11
Female
Germ Cells
Humans
Kidney Neoplasms
Polymorphism, Restriction Fragment Length

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Wilms Tumor

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Identifiers

PMID: 1973142
DOI: 10.1016/0888-7543(90)90179-x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1973142-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Constitutional and somatic deletions of two different regions of maternal chromosome 11 in Wilms tumor.PMID 1973142Read ↗

Loss of heterozygosity in Wilms' tumour involves two distinct regions of chromosome 11.Semantic proximity Read ↗

Loss of heterozygosity in Wilms' tumors, studied for six putative tumor suppressor regions, is limited to chromosome 11.Semantic proximity Read ↗

Somatic deletion and duplication of genes on chromosome 11 in Wilms' tumours.Semantic proximity Read ↗

Multiple genetic abnormalities of 11p15 in Wilms' tumor.Semantic proximity Read ↗

Loss of heterozygosity for chromosome region 11p15 in Wilms' tumours is not related to HRAS gene transforming mutations.Semantic proximity Read ↗

Allelotyping in Wilms tumors identifies a putative third tumor suppressor gene on chromosome 11.Semantic proximity Read ↗

Direct pulsed field gel electrophoresis of Wilms' tumors shows that DNA deletions in 11p13 are rare.Semantic proximity Read ↗

Duplications of chromosome 11p15 of maternal origin result in a phenotype that includes growth retardation.Semantic proximity Read ↗

Allele loss in Wilms tumors of chromosome arms 11q, 16q, and 22q correlate with clinicopathological parameters.Semantic proximity Read ↗

Constitutional and somatic mutations in the WT1 gene in Wilms' tumor patients.Semantic proximity Read ↗

A third Wilms' tumor locus on chromosome 16q.Semantic proximity Read ↗

Loss of heterozygosity at 11p13 in Wilms' tumours does not necessarily involve mutations in the WT1 gene.Semantic proximity Read ↗

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