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Article

A third Wilms' tumor locus on chromosome 16q.

Cancer research - 1 Jun 1992

Maw M A, Grundy P E, Millow L J, Eccles M R, Dunn R S, Smith P J, Feinberg A P, Law D J, Paterson M C, Telzerow P E

Abstract excerpt

Loss of heterozygosity studies have been used to identify chromosomal regions which are frequently deleted and thus indicate areas which may harbor tumor suppressor genes. As a result, both the WT1 gene located in chromosome 11p13 and an unidentified gene(s) within chromosome 11p15 have been implicated in Wilms' tumorigenesis. Cytogenetic and linkage studies suggest that additional non-chromosome 11 sites are...

Topics

Alleles
Chromosome Deletion
Chromosome Mapping
Chromosomes, Human, Pair 11
Chromosomes, Human, Pair 16
DNA, Neoplasm
Female
Genes, Tumor Suppressor
Heterozygote
Humans
Kidney Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Pedigree

Wilms Tumor

Source

Identifiers

PMID: 1317258

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1317258-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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A third Wilms' tumor locus on chromosome 16q.PMID 1317258Read ↗

Allele loss in Wilms tumors of chromosome arms 11q, 16q, and 22q correlate with clinicopathological parameters.Semantic proximity Read ↗

Clinicopathologic correlates of loss of heterozygosity in Wilm's tumor: a preliminary analysis.Semantic proximity Read ↗

Loss of heterozygosity on chromosome 16 in sporadic Wilms' tumour.Semantic proximity Read ↗

Allelotyping in Wilms tumors identifies a putative third tumor suppressor gene on chromosome 11.Semantic proximity Read ↗

Genome-wide loss of heterozygosity analysis of WT1-wild-type and WT1-mutant Wilms tumors.Semantic proximity Read ↗

Loss of heterozygosity at 11p13 in Wilms' tumours does not necessarily involve mutations in the WT1 gene.Semantic proximity Read ↗

Loss of heterozygosity in Wilms' tumors, studied for six putative tumor suppressor regions, is limited to chromosome 11.Semantic proximity Read ↗

Loss of heterozygosity for chromosome region 11p15 in Wilms' tumours is not related to HRAS gene transforming mutations.Semantic proximity Read ↗

Genetic and epigenetic alterations on the short arm of chromosome 11 are involved in a majority of sporadic Wilms' tumours.Semantic proximity Read ↗

Constitutional and somatic deletions of two different regions of maternal chromosome 11 in Wilms tumor.Semantic proximity Read ↗

Frequent loss of heterozygosity at 11p loci in testicular cancer.Semantic proximity Read ↗

Loss of heterozygosity in Wilms' tumour involves two distinct regions of chromosome 11.Semantic proximity Read ↗

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