Allelotyping in Wilms tumors identifies a putative third tumor suppressor gene on chromosome 11.

doi:10.1006/geno.1995.1082

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Article

Allelotyping in Wilms tumors identifies a putative third tumor suppressor gene on chromosome 11.

Genomics - 10 Jun 1995

Radice P, Perotti D, De Benedetti V, Mondini P, Radice M T, Pilotti S, Luksch R, Fossati Bellani F, Pierotti M A

Abstract excerpt

An analysis of loss of heterozygosity for markers on both the short and the long arm of chromosome 11 was performed in 24 sporadic Wilms tumors. Six cases (25%) showed allelic losses involving the entire chromosome. In one case (4%) the loss was restricted solely to the WT1 gene on band p13. Two...

Topics

Alleles
Chromosome Mapping
Chromosomes, Human, Pair 11
DNA, Neoplasm
Female
Genes, Wilms Tumor
Genetic Markers
Heterozygote
Humans
Kidney Neoplasms
Male
Wilms Tumor

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