Somatic deletion and duplication of genes on chromosome 11 in Wilms' tumours.

doi:10.1038/309176a0

Back to search

Article

Somatic deletion and duplication of genes on chromosome 11 in Wilms' tumours.

Nature - 1 Jan 2000

Fearon E R, Vogelstein B, Feinberg A P

Abstract excerpt

One of the most provocative findings in tumour biology is the relationship between chromosomal changes and embryonal cancers in children. For example, children with the rare paediatric syndrome AGR triad (aniridia, genito-urinary abnormalities and mental retardation) often develop Wilms' tumours...

Topics

Alleles
Base Sequence
Chromosome Deletion
Chromosomes, Human, 6-12 and X
Humans
Kidney
Kidney Neoplasms
Nucleic Acid Hybridization
Oncogenes
Reference Values
Wilms Tumor

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.