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Article

Loss of alleles at loci on human chromosome 11 during genesis of Wilms' tumour.

Nature - 1 Jan 2000

Koufos A, Hansen M F, Lampkin B C, Workman M L, Copeland N G, Jenkins N A, Cavenee W K

Abstract excerpt

Evidence that recessive cellular alleles at specific chromosomal loci are involved in tumorigenesis has been recently shown by work on tissues from patients with retinoblastoma, a neoplasm of embryonic retina whose predisposition is inherited as an autosomal dominant trait. A comparison of germ-line and tumour genotypes at loci on human chromosome 13, defined by restriction fragment length polymorphisms, showed...

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Identifiers

PMID: 6325936
DOI: 10.1038/309170a0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Loss of alleles at loci on human chromosome 11 during genesis of Wilms' tumour.PMID 6325936Read ↗

Genetic mosaicism in normal tissues of Wilms' tumour patients.Semantic proximity Read ↗

Expression of recessive alleles by chromosomal mechanisms in retinoblastoma.Semantic proximity Read ↗

Loss of heterozygosity in three embryonal tumours suggests a common pathogenetic mechanism.Semantic proximity Read ↗

Differences in patterns of allelic loss between two common types of adult cancer, breast and colon carcinoma, and Wilms' tumor of childhood.Semantic proximity Read ↗

Somatic deletion and duplication of genes on chromosome 11 in Wilms' tumours.Semantic proximity Read ↗

Loss of heterozygosity in Wilms' tumour involves two distinct regions of chromosome 11.Semantic proximity Read ↗

The beta-subunit of follicle-stimulating hormone is deleted in patients with aniridia and Wilms' tumour, allowing a further definition of the WAGR locus.Semantic proximity Read ↗

Tumor-suppressor genes: cardinal factors in inherited predisposition to human cancers.Semantic proximity Read ↗

An internal deletion within an 11p13 zinc finger gene contributes to the development of Wilms' tumor.Semantic proximity Read ↗

Constitutional and somatic deletions of two different regions of maternal chromosome 11 in Wilms tumor.Semantic proximity Read ↗

Preferential loss of maternal alleles in sporadic Wilms' tumour.Semantic proximity Read ↗

Loss of a Harvey ras allele in sporadic Wilms' tumour.Semantic proximity Read ↗

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