Article
Loss of alleles at loci on human chromosome 11 during genesis of Wilms' tumour.
Nature - 1 Jan 2000
Koufos A, Hansen M F, Lampkin B C, Workman M L, Copeland N G, Jenkins N A, Cavenee W K
Abstract excerpt
Evidence that recessive cellular alleles at specific chromosomal loci are involved in tumorigenesis has been recently shown by work on tissues from patients with retinoblastoma, a neoplasm of embryonic retina whose predisposition is inherited as an autosomal dominant trait. A comparison of germ-line and tumour genotypes at loci on human chromosome 13, defined by restriction fragment length polymorphisms, showed...
Topics
- Alleles
- Chromosomes, Human, 6-12 and X
- DNA Restriction Enzymes
- DNA, Neoplasm
- Genetic Carrier Screening
- Humans
- Kidney Neoplasms
- Mutation
- Wilms Tumor