Loss of heterozygosity at 11p13 in Wilms' tumours does not necessarily involve mutations in the WT1 gene.

doi:10.1038/bjc.1993.235

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Article

Loss of heterozygosity at 11p13 in Wilms' tumours does not necessarily involve mutations in the WT1 gene.

British journal of cancer - 1 Jun 1993

Cowell J K, Groves N, Baird P

Abstract excerpt

Loss of heterozygosity (LOH) in tumour cells is generally accepted as 'exposing' recessive cancer genes. The short arm of chromosome 11 shows consistent LOH in Wilms' tumours along its entire length. Occasionally, however, only the 11p13 and/or the 11p15 regions are involved. Deletions of the 11p...

Topics

Alleles
Chromosome Deletion
Chromosomes, Human, Pair 11
DNA, Neoplasm
Genes, Wilms Tumor
Heterozygote
Humans
Mutation
Wilms Tumor

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