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Article

Upf1 stimulates degradation of the product derived from aberrant messenger RNA containing a specific nonsense mutation by the proteasome.

EMBO reports - 1 Nov 2009

Kuroha Kazushige, Tatematsu Tsuyako, Inada Toshifumi

Abstract excerpt

Aberrant messenger RNAs containing a premature termination codon (PTC) are eliminated by the nonsense-mediated mRNA decay (NMD) pathway. Here, we show that a crucial NMD factor, up frameshift 1 protein (Upf1), is required for rapid proteasome-mediated degradation of an aberrant protein (PTC product) derived from a PTC-containing mRNA. Western blot and pulse-chase analyses revealed that Upf1 stimulates the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 19798102
DOI: 10.1038/embor.2009.200
PMCID: PMC2775173

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Source receipt: pubmed, retrieved 7 Sept 2026.

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