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Article

Aberrant mRNAs with extended 3' UTRs are substrates for rapid degradation by mRNA surveillance.

RNA (New York, N.Y.) - 1 Oct 1999

Muhlrad D, Parker R

Abstract excerpt

The mRNA surveillance system is known to rapidly degrade aberrant mRNAs that contain premature termination codons in a process referred to as nonsense-mediated decay. A second class of aberrant mRNAs are those wherein the 3' UTR is abnormally extended due to a mutation in the polyadenylation site. We provide several observations that these abnormally 3'-extended mRNAs are degraded by the same machinery that...

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Source

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Identifiers

PMID: 10573121
DOI: 10.1017/s1355838299990829
PMCID: PMC1369852

Genes

PGK1
UPF1
UPF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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