Article
Identification and characterization of genes that are required for the accelerated degradation of mRNAs containing a premature translational termination codon.
Genes & development - 15 Feb 1995
Cui Y, Hagan K W, Zhang S, Peltz S W
Abstract excerpt
In both prokaryotes and eukaryotes nonsense mutations in a gene can enhance the decay rate of the mRNA transcribed from the gene, a phenomenon described as nonsense-mediated mRNA decay. In yeast, the products of the UPF1 and UPF3 genes are required for this decay pathway, and in this report we fo...
Topics
- Adaptor Proteins, Signal Transducing
- Alleles
- Amino Acid Sequence
- Base Sequence
- Codon, Terminator
- Cycloheximide
- Fungal Proteins
- Genes, Fungal
- Genetic Complementation Test
- Molecular Sequence Data
- Mutation