Article
Association analysis of Wnt pathway genes on prostate-specific antigen recurrence after radical prostatectomy.
Annals of surgical oncology - 1 Jan 2010
Huang Shu-Pin, Ting Wen-Chien, Chen Lu-Min, Huang Li-Chia, Liu Chia-Chu, Chen Chien-Wei, Hsieh Chi-Jeng, Yang Wen-Hui, Chang Ta-Yuan, Lee Hong-Zin, Bao Bo-Ying
Abstract excerpt
BACKGROUND: Approximately one-third of prostate cancer (PCa) patients show biochemical failure after radical prostatectomy (RP) and are prone to develop metastasis with significant mortality. Although aberrant Wnt/beta-catenin (CTNNB1) signaling has been observed in numerous types of human cancers, including PCa, to our knowledge there is currently no information on the role of Wnt signaling gene polymorphisms in...
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